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Figure 1 | Respiratory Research

Figure 1

From: Activated mammalian target of rapamycin is associated with T regulatory cell insufficiency in nasal polyps

Figure 1

Infiltration of pmTOR+ cells and Foxp3+CD4+ cell in nasal tissues by histologic examination. The number of pmTOR+ cells was significantly higher in nasal polyps than in controls, whereas the number of Foxp3+CD4+ cells was significantly lower in nasal polyps than in controls. Representative images are provided and the results were analyzed by the unpaired t-test. (A), The pmTOR+ cells were located in both the epithelium and submucosa of nasal polyps; (B), Expression of pmTOR was primarily located in the submucosa of nasal polyps; (C) Immunostaining of pmTOR was localized primarily to the epithelium in control tissues; (D), Negative control for pmTOR staining in nasal polyps (200× magnification). (E and F), Foxp3+CD4+ cells were located in nasal polyps (E) and the control tissue (F), as evidenced by double immunofluorescence (400× magnification); CD4 FITC (green); Foxp3 Texas red (red); double-positive stain (arrow, orange).

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