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Figure 5 | Respiratory Research

Figure 5

From: Activated mammalian target of rapamycin is associated with T regulatory cell insufficiency in nasal polyps

Figure 5

Rapamycin modulates the levels of T cell cytokines in the supernatants of cultured nasal polyps, as determined by ELISA. Significant changes were observed in the levels of IFN-γ, IL-4, IL-5, and IL-10 by multiple comparisons (P < 0.0125 by the ANOVA test and Bonferroni correction) and Rapamycin was shown to enhance IL-10 production in nasal polyps. More Th1/Th2 and less Treg cytokines were demonstrated in nasal polyps (*P < 0.05 by the unpaired t-test for intragroup comparison). After rapamycin treatment, a slight decrease in Th1 and Th2 cytokines, IFN-γ, IL-4, and IL-5 (30%, 47%, and 41%, respectively;**P > 0.05 by the paired t-test for intragroup comparison), and a significant increase in IL-10 were found in nasal polyps (4.4-fold; **P < 0.05 by the paired t-test for intragroup comparison).

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