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Figure 2 | Respiratory Research

Figure 2

From: Hypoxia regulates human lung fibroblast proliferation via p53-dependent and -independent pathways

Figure 2

Expression of p21 and p53 mRNA in NHLF exposed tohypoxia or DFX. Cultured NHLF were exposed to 0.1% or 2% oxygen, or 100 μM DFX, for 24 h, then real-time RT-PCR analyses were performed. The amount of p21 mRNA was increased by severe hypoxia but decreased by moderate hypoxia. No significant changes were detected in the expression of p27 and p53 mRNA. The bar graph shows the ratios of p21 (open bars), p27 (solid bars), and p53 (shaded bars) mRNA relative to the amount of β-actin mRNA. Data are expressed as mean ± SE (n = 6). *P < 0.05 versus the 21% oxygen control.

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