Figure 1
Western blot analysis of fibrin deposition in lung homogenates of rat pups exposed to room air (RA), oxygen (O 2 ) and O 2 in combination with 100 mg/kg/day of sildenafil (Sil 100 ) for 10 days (panel A). Panel B shows quantification of fibrin deposition in lung homogenates on day 10. Experimental groups include room air-exposed controls (RA, white bar), age-matched O2-exposed controls (O2, black bar) and sildenafil-treated rat pups (50 mg/kg/day: Sil50, striped bar; 100 mg/kg/day: Sil100, gray bar) under hyperoxia. Quantification of cyclic GMP in lung homogenates (panel C) in room air-exposed littermates (white bars), O2-exposed control pups (black bars) and 100 mg/kg/day sildenafil-treated pups (Sil100, gray bars). Data are expressed as mean ± SEM of at least 6 pups per experimental group. *p < 0.05 and ***p < 0.001 versus age-matched O2-exposed controls. Δ p < 0.05 versus room air-exposed controls.