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Figure 5 | Respiratory Research

Figure 5

From: Sildenafil attenuates pulmonary inflammation and fibrin deposition, mortality and right ventricular hypertrophy in neonatal hyperoxic lung injury

Figure 5

Relative mRNA expression, determined with RT-PCR, of genes related to inflammation; interleukin-6 (IL-6; panel A), coagulation; tissue factor (TF; panel B), fibrinolysis; plasminogen activator inhibitor-1 (PAI-1; panel C) and alveolar growth; amphiregulin (panel D), vascular endothelial growth factor receptor-2 (VEGFR2; panel E) and fibroblast growth factor receptor-4 (FGFR4; panel F) in room air-exposed controls (RA, white bars), age-matched O 2 -exposed controls (O 2 , black bars) and sildenafil-treated rat pups (100 mg/kg/day [Sil 100 ], gray bars) on day 10. Data are expressed as mean ± SEM of 10 rat pups. *p < 0.05 and ***p < 0.001 versus age-matched O2-exposed controls.ΔΔΔ p < 0.001 versus room air-exposed controls.

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