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Table 4 Family-based association analysis of IPO13 polymorphisms on methacholine hyperresponsiveness (PC20) in childhood asthma.

From: Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma

 

Nedocromil/Placebo

Budesonide

Marker

Number of informative Families

P-value

Number of informative families

P-value

rs6671164

48

0.042

16

0.504

rs4448553

46

0.005

18

0.694

rs1990150

21

0.094

7

0.225

rs2240447

46

0.008

18

0.498

rs2486014

10

0.144

2

0.419

rs2301993

47

0.004

16

0.532

rs2301992

5

0.313

2

0.621

rs1636879

10

0.329

3

0.322

rs7412307

38

0.108

14

0.865

rs2428953

13

0.708

5

0.221

  1. Treatment-stratified analysis of repeated measures of methacholine PC20 performed using FBAT-PC as implemented in PBAT.