Table 5 Fold-change in methacholine PC20 by treatment group at 8-months post-randomization among IPO13 variant carriers
From: Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma
Budesonide (n = 214) | Nedocromil/Placebo (n = 440) | ||||
|---|---|---|---|---|---|
SNP | Fold change (95% CI) | p-value | Fold change (95% CI) | p-value | Test for interaction |
rs6671164 | 0.81 (0.38 – 1.68) | 0.56 | 1.65 (1.05 – 2.61) | 0.03 | 0.13 |
rs4448553 | 0.84 (0.40 – 1.77) | 0.65 | 1.58 (1.00 – 2.51) | 0.05 | 0.20 |
rs1990150 | 0.72 (0.31 – 1.69) | 0.45 | 2.25 (1.35 – 3.74) | 0.002 | 0.02 |
rs2240447 | 0.72 (0.34 – 1.53) | 0.39 | 1.82 (1.14 – 2.89) | 0.01 | 0.05 |
rs2486014 | 0.99 (0.37 – 2.62) | 0.98 | 1.97 (1.10 – 3.53) | 0.02 | 0.21 |
rs2301993 | 0.83 (0.39 – 1.79) | 0.64 | 1.80 (1.13 – 2.86) | 0.01 | 0.11 |
rs2301992 | 0.48 (0.15 – 1.52) | 0.21 | 1.64 (0.78 – 3.47) | 0.19 | 0.08 |
rs1636879 | 1.02 (0.38 – 2.74) | 0.96 | 2.14 (1.20 – 3.83) | 0.01 | 0.11 |
rs7412307 | 0.74 (0.34 – 1.60) | 0.44 | 1.84 (1.14 – 2.96) | 0.01 | 0.06 |
rs2428953 | 0.67 (0.26 – 1.70) | 0.40 | 2.30 (1.32 – 4.00) | 0.003 | 0.02 |