Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma

Respiratory Research

Table 6 Family-based haplotype association analysis of IPO13 polymorphisms on methacholine hyperresponsiveness (PC20) in childhood asthma.

	Nedocromil/Placebo (global p-value = 0.02)		Budesonide (global p-value = 0.58)
Haplotype	Number of informative families	P-value	Number of informative families	P-value
A	136	0.41	53	0.33
B	84	0.02	33	0.53
C	69	0.17	20	0.41
D	43	0.48	18	0.50

Haplotype analysis was performed using one of several haplotype-tagging SNP combinations: rs6671164 – rs199150 – rs2428953. The haplotype designations A through D correspond to those illustrated in Figure 1.

ISSN: 1465-993X