Figure 4

Gene expression analysis in nasal turbinate. 2-wk CS exposure resulted in increased levels of MCP-1 and FoxP3. Levels of RORc and subsequent IL-17 were significantly down-regulated at this time point (Fig. 4A). At 4-wk, GCP-2, but not KC, levels are increased. Moreover, FoxP3 is significantly higher in the CS exposed group (Fig. 4B). 24-wk CS exposure results in significant down-regulation of nasal MCP-1, MIP-3α an TGF-β1 (Fig. 4C). (n = 8 mice/group, *p < 0.05, **p < 0.01, ***p < 0.001).