Different regulation of cigarette smoke induced inflammation in upper versus lower airways

Respiratory Research

Table 2 Bronchoalveolar analysis

	2-wk Air	2-wk Smoke	4-wk Air	4-wk Smoke	24-wk Air	24-wk Smoke
Total cell number, (× 10³)	602.5 ± 41.20	797.53 ± 74.96*	410.00 ± 144.12	1046.00 ± 154.98^†	432.50 ± 37.97	845.00 ± 114.25^†
Neutrophils, (× 10³)	0.00 ± 0.00	62.59 ± 10.47^‡	0.00 ± 0.00	200.23 ± 50.97^‡	0.16 ± 0.16	99.75 ± 30.04^†
Macrophages, (× 10³)	598.55 ± 38.90	723.66 ± 61.59	408.71 ± 142.94	797.55 ± 103.16*	429.46 ± 37.56	719.10 ± 80.27^†
Lymphocytes, (× 10³)	2.49 ± 066	8.32 ± 1.42^†	1.29 ± 1.21	47.82 ± 8.19^‡	2.46 ± 0.32	26.15 ± 8.42^†
Eosinophils, (× 10³)	1.46 ± 1.46	2.96 ± 1.49	0.00 ± 0.00	0.39 ± 0.26	0.27 ± 0.18	0.00 ± 0.00

Subacute (4-wk) and chronic (24-wk) CS exposure caused a significant increase in the absolute numbers of total cells, alveolar macrophages, lymphocytes and neutrophils in the BAL fluid, compared to air exposed littermates. (Values are reported as mean ± SEM; n = 8 mice/group, *p < 0.05 versus Air, ^†p < 0.01 versus Air, ^‡p < 0.001 versus Air)

ISSN: 1465-993X