Figure 3From: Host lung gene expression patterns predict infectious etiology in a mouse model of pneumoniaEarly development of infection-specific transcription profiles. (A) Six hours after challenge with P. aeruginosa, S. pneumoniae, A. fumigatus or PBS (sham), lungs were removed and submitted to microarray analysis, and a heatmap was generated with green indicating decreased gene expression and red indicating increased gene expression. At this time, 4,274 genes were highly differentially expressed (FDR< 1 Ă— 10-7), and by unsupervised clustering, most samples self-segregated by challenge. (N = 6 sham infected mice, 8 mice for each infection.) (B) The 30 genes that were most strongly differentially expressed at 18 h after infection were examined at earlier time points, demonstrating the increasing clarity of the differential pattern. (N = 6 sham infected mice, 4 mice for each infection.)Back to article page