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Table 1 Summary of Change in Hemodynamic Outcomes with Intervention Compared to Placebo/Control

From: Pharmacotherapy in pulmonary arterial hypertension: a systematic review and meta-analysis

Drug Class

mPAP

mRAP

PVR

Cardiac Index

Prostanoids

-4.2 (-6.2, -2.1)

-1.6 (-2.3, -0.9)

-291 (-401, -182)

0.32 (0.12, 0.52)

Endothelin receptor antagonists

-4.9 (-6.6, -3.2)

-1.4 (-2.9, 0.2)

-245 (-316, -174)

0.30 (0.09, 0.51)

Phosphodiesterase type 5 inhibitors

-4.2 (-5.7, -2.7)

-1.8 (-2.8, -0.8)

-192 (259, 126)

0.39 (0.15, 0.63)*

  1. Data are reported as mean placebo/control-corrected change (95% confidence interval)
  2. mPAP, mean pulmonary artery pressure; mRAP, mean right atrial pressure; PVR, pulmonary vascular resistance
  3. * reported only in Galie et al, 2005 [29]