From: Pharmacotherapy in pulmonary arterial hypertension: a systematic review and meta-analysis
Event | Number of studies | Number of participants | RR | 95% CI |
---|---|---|---|---|
Prostanoids* | Â | Â | Â | Â |
   Jaw pain | 5 | 893 | 4.87 | 2.01 to 11.76 |
   Diarrhea | 4 | 826 | 2.62 | 1.40 to 4.89 |
   Peripheral edema | 3 | 652 | 2.22 | 1.22 to 4.07 |
   Headache | 4 | 782 | 1.96 | 1.10 to 3.47 |
   Nausea | 5 | 893 | 1.57 | 1.23 to 2.00 |
Phosphodiesterase type 5 inhibitors* | Â | Â | Â | Â |
   Visual disturbance | 3 | 567 | 3.83 | 1.19 to 12.30 |
   Dyspepsia | 3 | 567 | 3.77 | 1.92 to 7.43 |
   Flushing | 3 | 567 | 2.11 | 1.31 to 3.39 |
   Headache | 3 | 567 | 1.73 | 1.19 to 2.51 |
   Limb pain | 3 | 567 | 1.67 | 1.10 to 2.53 |