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Figure 4 | Respiratory Research

Figure 4

From: Cigarette smoke induces PTX3 expression in pulmonary veins of mice in an IL-1 dependent manner

Figure 4

Effect of IL-1RI deficiency on cigarette smoke (CS)-induced vascular PTX3 expression. (A) Quantification of PTX3 in lung homogenate by ELISA. (B) Quantification of PTX3 stained endothelial cell layer of lung blood vessels. The amount of PTX3 expression measured in a subacute (4 weeks) experiment was normalized for the length of internal perimeter. Photomicrographs of PTX3 immunostained venules of (C) air-exposed WT, (D) CS-exposed WT, (E) air-exposed IL-1RI KO and (D) CS-exposed IL-1RI KO (magnification: 200×). Data are expressed as mean ± SEM (N = 8-10 animals/group; * p < 0.05, ** p < 0.01 and *** p < 0.01).

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