Figure 5
From: Expression and function of human hemokinin-1 in human and guinea pig airways
Cross-desensitization of NK 1 receptors after consecutive applications of hHK-1 (3.10 -7 M) and [Sar 9 ,Met(O 2 ) 11 ] SP (10 -7 M) on human bronchi ( n = 5). All combinations of hHK-1 and [Sar9,Met(O2)11] SP were assessed. Experiments were performed in the presence of phosphoramidon (10-6 M). Values are expressed in percentage (mean ± s.e.m.) of maximal contraction obtained with ACh 3 mM. Statistical analysis was performed with two-way ANOVA for repeated measures followed with Bonferroni post-test. ** p < 0.01 and *** p < 0.001 for contraction obtained after the second application versus the first application. (Sar9 = [Sar9,Met(O2)11] SP).