Figure 7
From: Expression and function of human hemokinin-1 in human and guinea pig airways
Cumulative concentration-response curves to hHK-1 on guinea pig trachea (A and B) and main bronchi (C) pre-treated with NK 1 or NK 2 receptor antagonists. (A) Cumulative additions of hHK-1 on guinea pig trachea in the absence (control) and presence of various concentrations of NK1 receptor antagonist SR 140333 (10-9 to 10-7 M) (n = 4-11). (B) Cumulative additions of hHK-1 on guinea pig trachea in the absence (control) and presence of NK2 receptor antagonist SR 48968 (10-7 M) (n = 6). (C) Cumulative additions of hHK-1 on guinea pig main bronchi in the absence (control) and presence of NK1 or NK2 receptor antagonists SR 140333 and SR 48968 (10-7 M) (n = 5-7). Experiments were performed in the presence of phosphoramidon (10-6 M). Values are expressed in percentage (mean ± s.e.m.) of maximal contraction obtained with ACh 3 mM. Statistical analysis was performed with two-way ANOVA for repeated measures followed with Bonferroni post-test. * p < 0.05, ** p < 0.01 and *** p < 0.001 versus paired control.