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Figure 2 | Respiratory Research

Figure 2

From: Effect of neutrophil elastase and its inhibitor EPI-hNE4 on transepithelial sodium transport across normal and cystic fibrosis human nasal epithelial cells

Figure 2

Effect of hNE and trypsin on transepithelial Na + transport across control and CF HNEC. HNEC from control (panel A) or CF (ΔF508) patients (panel B) grown on Snapwell filters and mounted in Ussing chamber were exposed apically to hNE, trypsin or vehicle. ΔI sc was calculated as the difference between the value of short-circuit current (I sc) at the end of exposure to drug or vehicle and the baseline I sc at the moment of drug or vehicle addition. Results are expressed in μA/cm2 and represent means ± SE of five to seven filters for each condition: vehicle, hNE (10 μg/ml), hNE (33 μg/ml), and trypsin (100 μg/ml).

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Respiratory Research

ISSN: 1465-993X

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