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Figure 2 | Respiratory Research

Figure 2

From: Disrupted postnatal lung development in heme oxygenase-1 deficient mice

Figure 2

Dexamethasone treatment disrupts postnatal alveolar development. A, B: Representative H&E staining of mouse lung sections at P10. Wildtype newborn mice were injected daily with saline (Control in A) or 1 ug/pup dexamethasone (Dex, in B). Note the enlarged alveolar airspace and thinning of the alveolar wall in Dex-treated animals (B). C. Lung alveolar counts in control and Dex-treated mice. * P < 0.05 vs. Control. D. HO protein levels in control and Dex-injected lungs. Upper panel: representative Western blot of P10 lungs from Control and Dex-injected mice with antibodies against HO-1, HO-2 and ß-actin (loading control). Samples from two animals for each group are shown. HO-1 protein levels were visibly decreased in Dex-injected samples, whereas HO-2 protein levels remained unchanged. Lower panel: densitometric values for HO-1 protein levels normalized with ß-actin, and expressed as ratio to control. * P < 0.05 vs. Control.

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