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Figure 3 | Respiratory Research

Figure 3

From: DMF inhibits PDGF-BB induced airway smooth muscle cell proliferation through induction of heme-oxygenase-1

Figure 3

DMF activates phosphorylation of p38 MAP kinase and p38 MAPK inhibition reduces DMF induced HO-1 in ASMC. (A) a representative immuno-blot of the PDGF-BB induced ERK1/2 MAPK (p-ERK1/2) phosphorylation kinetic in the presence and absence of DMF. Similar results were obtained in three additional cell lines. (B) a representative immuno-blot of the kinetic of PDGF-BB induced ERK1/2 MAPK (p-ERK1/2) phosphorylation and its enhancement by DMF; similar results were obtained in three cell lines. (C) a representative immuno-blot of DMF-induced HO-1 expression and its reduction by the p38 MAPK inhibitor SB203580 Similar results were obtained in three cell lines.

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