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Table 1 Study Population of Airway Epithelial Samples 1

From: Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium

 

Large airways

Small airways

Parameter

Healthy nonsmokers

Healthy smokers

Healthy nonsmokers

Healthy smokers

n

21

31

47

58

Sex (male/female)

15/6

21/10

33/14

38/20

Age (yr)

41 ± 8

44 ± 7

42 ± 11

43 ± 7

Race (B/W/O)2

10/7/4

20/7/4

23/18/6

35/14/9

Smoking history (pack-yr)

0

28 ±18

0

28 ± 17

Urine nicotine (ng/ml)

Negative

746 ± 904

Negative

1298 ±1692

Urine cotinine (ng/ml)

Negative

973 ± 690

Negative

1246 ± 974

Venous CO-Hb3

0.64 ± 0.93

2.0 ±1.9

0.4 ± 0.8

1.8 ± 1.9

Pulmonary function4

    

   FVC

106 ± 13

110 ± 11

107 ± 14

109 ± 13

   FEV1

107 ± 17

110 ± 12

106 ± 15

107 ± 14

   FEV1/FVC

82 ± 5

81 ± 5

82 ± 6

80 ± 5

   TLC

100 ± 14

103 ± 11

101 ±13

100 ±12

   DLCO

101 ± 16

95 ± 11

99 ± 15

94 ± 11

Epithelial cells

    

Total number × 106

7.0 ± 3

7.0 ± 3.3

6.3 ± 2.9

7.2 ± 3.0

   % epithelial

99.7 ± 0.6

99.8 ± 0.5

99.3 ± 1.1

99.1 ± 1.3

   % inflammatory

0.3 ± 0.6

0.2 ± 0.5

0.7 ± 1.1

0.8 ± 1.3

Differential cell count (%)

    

   Ciliated

53.6 ± 6.6

47.8 ± 13.7

74.3 ± 7.4

65.7 ± 12.5

   Secretory

10 ± 4.4

10 ± 4.1

6.6 ± 3.5

9.1 ± 4.5

   Basal

22.4 ± 3.4

25.9 ± 9.9

11.1 ± 5.3

12.7 ± 6.7

   Undifferentiated

14.1 ± 5.2

16.5 ± 8.9

7.3 ± 3.2

11.8 ± 6.7

  1. 1Data are presented as mean ∀ standard deviation.
  2. 2B = Black, W = White, O = Other.
  3. 3Venous carboxyhemoglobin, a secondary marker of current smoking; nonsmokers, normal value <1.5%.
  4. 4Pulmonary function testing parameters are given as % of predicted value with the exception of FEV1/FVC, which is reported as % observed; FVC - forced vital capacity, FEV1 - forced expiratory volume in 1 sec, TLC - total lung capacity, DLCO - diffusing capacity.