Table 4 The role of leptin in OSAHS and OHS
From: The role of leptin in the respiratory system: an overview
Reference (year) | Main message | Main limitations |
|---|---|---|
Ip et al68 (2000) | Leptin significantly correlated with AHI | Only males/Limited number of patients/Potential influence by comorbidities/No adjustment for FM |
Campo et al78 (2007) | Higher leptin is associated with reduced respiratory drive and reduced hypercapnic response | Conditions of blood sampling unknown/Potential influence by comorbidities |
Philips et al82 (2000) | Increased leptin in OSAHS | Only males/Limited number of patients/Low statistical power |
Barcelo et al86 (2005) | Decrease in leptin after nCPAP treatment in non-obese OSAHS | Only males/Limited number of patients/No adjustment for FM |
Shimizu et al90 (2002) | Significant decrease in leptin after 1 day of nCPAP The decrease of leptin correlated with cardiac sympathetic function | Only males/Limited number of patients/Potential influence by comorbidities Low statistical power |
Phipps et al96 (2002) | Leptin is a predictor for the presence of hypercapnia | Limited number of patients/Sex unknown |