From: The role of leptin in the respiratory system: an overview
Mechanism studied | Reference (year) | Main message | Main limitations |
---|---|---|---|
Cachexia-stable COPD | Takabatake et al102 (1999) | Leptin production regulated physiologically and not correlated with TNF-α or sTNF-R | Only males/Limited number of patients/No adjustment for FM |
 | Takabatake et al104 (2001) | Absence of circadian rhythm of leptin | Only males/Limited number of patients |
 | Schols et al106 (1999) | Leptin related to sTNF-R55 in emphysema | Only males/Limited number of patients/Patients received CS |
Exacerbation | Creutzberg et al108 (2000) | Increased leptin (serial measurements) Leptin positively correlated with sTNFR-55 | Limited number of patients/Patients with hospital stay < 7 days excluded/Patients received CS/Only severe COPD |
 | Kythreotis et al109 (2009) | Leptin positively correlated with TNF-α | Patients received CS |