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Table 5 The role of leptin in COPD

From: The role of leptin in the respiratory system: an overview

Mechanism studied

Reference (year)

Main message

Main limitations

Cachexia-stable COPD

Takabatake et al102

(1999)

Leptin production regulated physiologically and not correlated with TNF-α or sTNF-R

Only males/Limited number of patients/No adjustment for FM

 

Takabatake et al104 (2001)

Absence of circadian rhythm of leptin

Only males/Limited number of patients

 

Schols et al106 (1999)

Leptin related to sTNF-R55 in emphysema

Only males/Limited number of patients/Patients received CS

Exacerbation

Creutzberg et al108 (2000)

Increased leptin (serial measurements)

Leptin positively correlated with sTNFR-55

Limited number of patients/Patients with hospital stay < 7 days excluded/Patients received CS/Only severe COPD

 

Kythreotis et al109 (2009)

Leptin positively correlated with TNF-α

Patients received CS

  1. Abbreviations: FM: fat mass, CS: corticosteroids