Table 8 The role of leptin in infectious diseases of the lung
From: The role of leptin in the respiratory system: an overview
Infectious disease | Reference (year) | Main message | Main limitations |
|---|---|---|---|
Pneumonia | Mancuso et al150 (2002) | Klebsiella pneumonia administration results in increased leptin (WT mice) and increased mortality (ob/ob mice) | Experimental condition not well corresponding with clinical pneumonia/Only female mice |
| Â | Hsu et al152 (2007) | Increased mortality following pneumonococcal pneumonia (ob/ob mice) Leptin administration improves survival | Experimental conditions not well corresponding with clinical pneumonia/Only female mice |
| Â | Diez et al155 (2008) | No differences in leptin in pneumonia vs controls Leptin lacks prognostic value for pneumonia lethality | Possible influence by comorbidities/Only hospitalized patients included |
Tuberculosis | Buyukoglan et al159 (2007) | Lower leptin in tuberculosis | No adjustment for FM/Higher BMI in controls/Limited number of patients |
| Â | van Crevel et al161 (2002) | Leptin increases during antituberculous treatment | No adjustment for FM |
| Â | Cakir et al163 (1999) | Higher leptin in tuberculosis No significant difference in leptin before and after antituberculous treatment | No adjustment for FM/Limited number of patients |