Figure 7
Inhibition of reverse-mode NCX1 by KB-R7943 results in decreased agonist induced Ca 2+ signals. (Ai) Representative experimental trace from one experiment (average of 5 wells) illustrating BK (1 μM) induced changes in [Ca2+]i (presented as fluorescence intensity (FI)). (Aii) Summary of the data illustrated in (Ai) showing averaged peak fluorescence data, following addition of BK (n = 6). (Bi) Representative experimental trace from one experiment (average of 5 wells) illustrating HA (10 μM) induced changes in [Ca2+]i (ii). Summary of the data illustrated in (Ai) showing averaged peak fluorescence data, following addition of HA (n = 4). Summary graphs (Ai &Bi) are expressed as % changes ± sem compared to control and represent averaged data from at least 4 different experiments. Statistical analysis (paired Student T Test) was performed on the raw data and are indicated as significant with *P < 0.05 and **P < 0.01.