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Figure 5 | Respiratory Research

Figure 5

From: The laminin β1-competing peptide YIGSR induces a hypercontractile, hypoproliferative airway smooth muscle phenotype in an animal model of allergic asthma

Figure 5

Effects of immobilized and soluble YIGSR on basal and PDGF-induced human ASM cell proliferation. (A) Culturing of human ASM cells on immobilized YIGSR matrices inhibits PDGF-induced thymidine-incorporation in a YIGSR concentration-dependent fashion. Under unstimulated (Basal) conditions, no effects of immobilized YIGSR were observed. (B) Immobilized RGDS or its negative control GRADSP did not affect basal or PDGF-induced thymidine-incorporation. (C) The inhibitory effects of immobilized laminin-111 and YIGSR matrices on PDGF-induced thymidine-incorporation were normalized by soluble YIGSR. ***P < 0.001 compared to thymidine-incorporation of unstimulated cells (basal) cultured on uncoated matrices (plastic). #P < 0.05 and ##P < 0.01 compared to PDGF-induced thymidine-incorporation of cells cultured on uncoated matrices. Data represent means ± SEM of 4-5 independent experiments of 3 different donors, performed in duplicate.

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Respiratory Research

ISSN: 1465-993X

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