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Table 1 Contractile responses of epithelium-denuded, tracheal smooth muscle preparations after repeated saline or ovalbumin challenge of saline- or YIGSR-treated guinea pigs.

From: The laminin β1-competing peptide YIGSR induces a hypercontractile, hypoproliferative airway smooth muscle phenotype in an animal model of allergic asthma

Treatment

Challenge

Methacholine

KCl

n

  

E max (g)

pEC 50 (- log M)

E max (g)

EC 50 (mM)

 

Saline

Saline

1.42 ± 0.09

6.55 ± 0.18

1.02 ± 0.06

23.7 ± 0.9

6

YIGSR

Saline

1.84 ± 0.04

6.82 ± 0.13

1.41 ± 0.04*

20.4 ± 2.2

5

Saline

Ovalbumin

2.33 ± 0.22***

6.28 ± 0.11

1.73 ± 0.13**

23.7 ± 1.2

7

YIGSR

Ovalbumin

3.11 ± 0.18***, ###

6.61 ± 0.08

2.12 ± 0.19***,#

24.5 ± 1.1

7

  1. Data represent means ± SEM. Abbreviations: Emax : maximal contractile effect; EC50: concentration of the stimulus eliciting half-maximal response; pEC50: negative logarithm of the EC50 value. *P < 0.05, **P < 0.01, ***P < 0.001 compared to saline-treated, saline-challenged animals. #P < 0.05, ###P < 0.001 compared to saline-treated, ovalbumin-challenged animals.