Skip to main content

Table 1 Subject demographics, pulmonary function and body composition

From: Cardiovascular and musculskeletal co-morbidities in patients with alpha 1 antitrypsin deficiency

 

Controls

n = 20

Patients

n = 19

P value

Age (years)

61.1 (9.1)

59.2 (12.1)

0.59

Men n (%)

13 (65%)

12 (63%)

 

Smoking pack year*

5.5 (0-70)

10.0 (0-60)

0.69

FEV 1 (% predicted)

100.8 (12.5)

42.7 (23.3)

< 0.001

FVC (% predicted)

106.7 (17.5)

87.2 (25.6)

0.008

TLCO (mmol/min/kPa)

ND

4.1 (1.3)

 

Oxygen saturation (%)

97 (1)

92 (4)

0.008

PaO 2 (kPa)*

ND

8.9 (2.0)

 

6 MWD (m)

497 (80)

312(133)

< 0.001

Height (m)

1.69 (0.06)

1.71 (0.10)

0.42

Weight (kg)

80.5 (14.8)

69.4 (12.0)

0.014

BMI (kg/m 2 )

28.3 (4.0)

23.7 (3.0)

0.001

FFMI (kg/m 2 )

18.6 (2.6)

15.7 (1.7)

< 0.001

SGRQ - total

ND

52.0 (15.2)

 

Physical activity score

40 (9)

33 (5)

0.006

  1. All data represented as mean (standard deviation) unless otherwise indicated
  2. *median (range)
  3. Abbreviations: FEV 1 Forced Expiratory Volume 1 second, FVC Forced Vital Capacity, TLCO Total Lung Carbon Monoxide Transfer Factor, PaO 2 Arterial oxygen tension, 6MWD 6 Minute Walk Distance, BMI Body mass Index, FFMI Fat Free Mass Index, SGRQ St Georges Respiratory Questionnaire
  4. ND not determined