From: Cardiovascular and musculskeletal co-morbidities in patients with alpha 1 antitrypsin deficiency
 | Controls n = 20 | Patients n = 19 | P value |
---|---|---|---|
Age (years) | 61.1 (9.1) | 59.2 (12.1) | 0.59 |
Men n (%) | 13 (65%) | 12 (63%) | Â |
Smoking pack year* | 5.5 (0-70) | 10.0 (0-60) | 0.69 |
FEV 1 (% predicted) | 100.8 (12.5) | 42.7 (23.3) | < 0.001 |
FVC (% predicted) | 106.7 (17.5) | 87.2 (25.6) | 0.008 |
TLCO (mmol/min/kPa) | ND | 4.1 (1.3) | Â |
Oxygen saturation (%) | 97 (1) | 92 (4) | 0.008 |
PaO 2 (kPa)* | ND | 8.9 (2.0) | Â |
6 MWD (m) | 497 (80) | 312(133) | < 0.001 |
Height (m) | 1.69 (0.06) | 1.71 (0.10) | 0.42 |
Weight (kg) | 80.5 (14.8) | 69.4 (12.0) | 0.014 |
BMI (kg/m 2 ) | 28.3 (4.0) | 23.7 (3.0) | 0.001 |
FFMI (kg/m 2 ) | 18.6 (2.6) | 15.7 (1.7) | < 0.001 |
SGRQ - total | ND | 52.0 (15.2) | Â |
Physical activity score | 40 (9) | 33 (5) | 0.006 |