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Table 2 Association between year 15 serum adiponectin concentrations and year 10 lung function; CARDIA "calendar years".

From: Serum adiponectin is positively associated with lung function in young adults, independent of obesity: The CARDIA study

Year 15 adiponectin quartiles (Q)

YEAR 10 LUNG FUNCTION PARAMETERS (95% CI)

 

MODEL 1 (n = 2,056)

MODEL 2 (n = 2,056)

 

Year 10 FVC (ml) ± SE

Q1

4298 ± 23

4327 ± 24

Q2

4353 ± 24

4357 ± 24

Q3

4420 ± 22

4409 ± 22

Q4

4380 ± 25

4357 ± 25

Q1 minus Q4

-81 (-153, -9)

-30 (-103, 43)

Slope of ln(adiponectin)*

-82 (-140, -23)

-35 (-94, 25)

 

p for trend = 0.005

p for trend = 0.25

 

Year 10 FEV 1 (ml) ± SE

Q1

3448 ± 19

3469 ± 20

Q2

3476 ± 20

3479 ± 20

Q3

3539 ± 18

3531 ± 18

Q4

3498 ± 20

3481 ± 20

Q1 minus Q4

-50 (-109, 9)

-12 (-72, 48)

Slope of ln(adiponectin)*

-61 (-109, -13)

-27 (-76, 23)

 

p for trend = 0.01

p for trend = 0.28

 

Year 10 FEV 1 /FVC (%) ± SE

Q1

80.7 ± 0.2

80.6 ± 0.3

Q2

80.3 ± 0.3

80.3 ± 0.3

Q3

80.5 ± 0.2

80.5 ± 0.2

Q4

80.3 ± 0.3

80.4 ± 0.3

Q1 minus Q4

0.4 (-0.4, 1.1)

0.3 (-0.5, 1.1)

Slope of ln(adiponectin)*

0.11 (-0.51, 0.73)

0.03 (-0.61, 0.68)

 

p for trend = 0.73

p for trend = 0.92

  1. Note 1: Model 1 was adjusted for race, sex, center, age, age2, amount of self-reported physical activity, body mass index (BMI) and smoking status (never, former, current) all at year 15 and height, height2at year 0. Model 2 was adjusted for all covariates in model 1 and for ln(insulin resistance in HOMA units) and ln(CRP) at year 15 examination.
  2. Note 2: Quartile cutpoints for serum adiponectin concentrations are ≤6.99, 7.00-9.59, 9.60-14.39, and ≥ 14.40 mg/l. Mean ± standard deviation of ln(adiponectin) = 2.21 ± 0.62 mg/l
  3. * Unit of slope was selected to match the adiponectin difference across Q1 to Q4. It was ml/(median level of adiponectin in quartile 1 (4.8 mg/l) - median level of adiponectin in quartile 4 (18.0 mg/l)).