Figure 1

Effects of β-E2 on chronic hypoxia-induced pulmonary vascular structure remodeling of rats. (a) Hematoxylin and eosin staining of pulmonary arterioles (original magnification ×20). (b) Medial wall thickness (MT%) of pulmonary arterioles. (c) Medial wall area (MA%) of pulmonary arterioles. Scale bars = 50 μm. *P < 0.01, significant difference from the normoxia group. ^# P < 0.01, significant difference from the hypoxia group. Arterioles of external diameter ranged from 50-200 μm, 5-6 vessels per animal, total 40 small arteries for each group, were obtained. Values are expressed as mean ± SD (n = 40).