| Factor 1 | Factor 2 | Factor 3 | Factor 4 | Factor 5 | Factor 6 |
---|---|---|---|---|---|---|
Age, years | 0.226 | Â | Â | Â | Â | Â |
BMI, kg/m2 | Â | 0.272 | Â | -0.123 | 0.117 | Â |
Gender (% male) | 0.181 | -0.119 | 0.153 | Â | Â | -0.712 |
Pack-years of smoking | Â | Â | Â | Â | Â | 0.187 |
Age started smoking | Â | Â | Â | Â | Â | -0.237 |
Age quit smoking | 0.146 | 0.14 | Â | Â | Â | -0.11 |
Pre-bronchodilator FEV1, % predicted | 0.852 | Â | 0.466 | Â | -0.181 | 0.1 |
Pre-bronchodilator FVC, % predicted | 0.903 | Â | -0.247 | Â | Â | 0.154 |
Post-bronchodilator FEV1, % predicted | 0.853 | Â | 0.461 | Â | 0.209 | Â |
Post-bronchodilator FVC, % predicted | 0.899 | Â | -0.301 | Â | 0.172 | 0.193 |
Bronchodilator response, % of baseline FEV1 | Â | Â | Â | Â | 0.979 | Â |
Bronchodilator response, absolute change in FEV1, L | 0.163 | Â | Â | Â | 0.943 | 0.183 |
FEV1/FVC ratio, post-bronchodilator | 0.104 | Â | 0.961 | Â | Â | -0.134 |
FEV1/FVC ratio, pre-bronchodilator | Â | Â | 0.902 | Â | -0.106 | Â |
Total lung capacity, % predicted | Â | -0.165 | -0.227 | 0.151 | Â | Â |
Residual volume, % predicted | -0.506 | Â | -0.145 | 0.199 | -0.132 | Â |
Diffusion capacity, % predicted | 0.169 | Â | 0.219 | -0.253 | Â | 0.286 |
Total fraction emphysema at -950 HU | Â | -0.214 | -0.178 | 0.822 | Â | Â |
Difference between apical and basal emphysema at -950 HU | Â | Â | Â | 0.846 | Â | -0.108 |
Apical fraction emphysema at -950 HU | Â | -0.141 | Â | 0.981 | Â | Â |
Airway wall thickness, mm | Â | 0.96 | Â | Â | Â | Â |
Airway wall area, % | Â | 0.94 | Â | -0.114 | Â | Â |
Square root wall area, cm | Â | 0.882 | Â | Â | Â | Â |
6 minute walk distance, ft | 0.175 | -0.105 | Â | Â | 0.104 | 0.566 |
Maximum work, watts | 0.174 | Â | 0.135 | -0.1 | 0.164 | 0.791 |
UCSD Shortness of Breath Questionnaire | -0.227 | Â | Â | Â | Â | -0.307 |
Arterial pH | 0.212 | Â | 0.107 | 0.146 | Â | Â |
PaO2, mmHg | 0.2 | Â | 0.205 | Â | Â | 0.256 |
PaCO2, mmHg | -0.293 | Â | -0.345 | -0.104 | Â | -0.166 |
Exacerbations in year prior to randomization | Â | -0.123 | Â | Â | Â | -0.113 |
Exacerbations/year (over 3.3 years) | Â | -0.107 | -0.204 | Â | Â | 0.152 |