Figure 1

Proteoglycan staining in lung sections from COPD patients. Representative micrographs of lung sections from one COPD patient. Antibodies were visualized by DAB staining (shown in brown) and sections were counterstained with Mayer's hematoxylin, which stains cell nuclei blue. A, C, E, and G (left panel) are representative micrographs from the central airways (bronchi) and B, D, F, and H (right panel) show the small airways and parenchyma. A and B show versican, C and D perlecan, E and F biglycan, and G and H decorin. L denotes lumen of the bronchi, and A and V denote airway and vessels, respectively. Black arrowheads show staining in the lamina reticularis. Scale bars represent 100 μm.