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Table 2 Immunoreactivity scores for claudin-1, -3, -4, -5 and-7 in different types of pulmonary cells in developing human lung during various gestational periods.

From: Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung

Claudin type

Pseudo-glandular period

day 52-week 16

13 cases

(scores/number of cases)

Canalicular period

weeks 16-28

17 cases

(scores/number of cases)

Saccular period

weeks 28-36

9 cases

(scores/number of cases)

Alveolar period

weeks 36-40

8 cases

(scores/number of cases)

Claudin-1

    

bronchus

+/10, ++/3

+++/17

++/8, +++/1

++/1, +++/7

bronchioles

 

+/5, ++/12

+/8, ++/1

++/5, +++/3

   - large

+/13

   

   - small

negative/13

   

alveolus

# negative/13

negative/17

negative/9

negative/8

endothelial cell

negative/13

negative/17

negative/9

negative/8

Claudin-3

    

bronchus

+++/13

+++/17

+++/9

+++/8

bronchiolus

++/6, +++/7

+++/17

+++/9

+++/8

alveolus

# +/4, ++/9

* +/8, ++/9

& +/7, ++/2

& +/7,++/1

endothelial cell

negative/13

negative/17

negative/9

negative/8

Claudin-4

    

bronchus

+++/13

+++/17

+++/9

+++/8

bronchiolus

+++/13

+++/17

+++/9

+++/8

alveolus

# +/3, ++/10

* +/4, ++/13

& +/5 ++/4

& +/2 ++/6

endothelial cell

negative/13

negative/17

negative/9

negative/8

Claudin-5

    

bronchus

+/13

+/17

+/9

+/8

bronchiolus

+/13

+/17

+/9

+/8

alveolus

# +/13

* +/17

negative/9

negative/8

endothelial cell

+++/13

+++/17

+++/9

+++/8

Claudin-7

    

bronchus

+++/13

+++/17

+++/9

+++/8

bronchiolus

++/3, +++/10

+++/17

+++/9

+++/8

alveolus

# +/13

* +/7,++/9, +++/1

& +/8, ++/1

& +/8

endothelial cell

negative/13

negative/17

negative/9

negative/8

  1. # = small developing airways, not alveoli
  2. * = pretype II cells
  3. & = type II pneumocytes