Figure 10From: Inhibition of IFN-γ-dependent antiviral airway epithelial defense by cigarette smoke Model for cigarette smoke effects on type II interferon signal transduction. Cigarette smoke inhibits type II interferon-dependent gene expression by decreasing Stat1 phosphorylation. A portion of this effect is mediated by reactive oxygen species (ROS). Decreased antiviral gene expression decreases epithelial cell responses to IFN-γ that inhibit viral infection.Back to article page