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Figure 6 | Respiratory Research

Figure 6

From: K+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport

Figure 6

K+channel blockers alter the inhibitory effects of verapamil in H441 cells. (A) Typical Isc traces showing the application of 100 μM verapamil alone (control), 100 μM clofilium (KV inhibitor), 20 μM tram34 (KCa3.1 inhibitor), and 100 μM glibenclamide (KATP inhibitor), respectively. These K+ channel blockers were applied to basolateral side followed by verapamil and amiloride (apical side) to compute total AS Isc. (B) Summary of average AS Isc levels. Paired t-test. *P < 0.05, **P < 0.01, *** P < 0.001 for comparison of pre- and post exposure of CCB. n = 4-17. (C) Reduced percentages of AS Isc levels by verapamil in H441 cells with and without pretreatment of K+ channel blockers. Two-sample, two-tailed t-test. *P < 0.05 vs Control. n = 4-17.

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