Statins as potential therapeutic drug for asthma?

Respiratory Research

Table 3 Studies which report airway and serum inflammation after statin treatment

Study	Study type	Group	Sample (Trial/Control)	Duration of treatment	Results (statin group compared with the control group)
Braganza et al., [16]	RCT	Atorvastatin(40mg/day) vs placebo	71	4 weeks	No significant difference
Menzies et al., [21]	RCT	Simvastatin(20mg/day,40mg/day) vs placebo	16	4 weeks	0.86 geometric mean fold decrease in F_ENO and −0.18 doubling dilution shift in PC10 ↓
Hothersall et al., [22]	RCT	Atorvastatin(40mg/day) vs placebo	54	8 weeks	macrophage count (p=0.029) and sputum fluid leucotriene B4 (p=0.014) ↓
Maneechotesuwan et al., [15]	RCT	Simvastatin(10mg/day vs placebo	47(25/22)	8 weeks	Sputum eosinophil percentages (p=0.02) ↓
Cowan et al., [25]	RCT	Simvastatin(40mg/day) vs placebo	43	4 weeks	Sputum eosinophils (p=0.033) ↓
Al Obaidiet al., [29]	Controlled clinical trial	Simvastatin vs baseline	20	Not mentioned	ECP and CRP ↓

PC10= Concentration of methacholine that reduces FEV₁ by 10%; F_ENO= Fractional of exhaled nitric oxide; ECP=Serum eosinophil cationic protein , CRP=C-reactive protein.
↓ The airway and serum inflammation levels were lowering after statins treatment.

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