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Table 3 Cell surface phenotype expression pre and post ozone exposure

From: Individuals with increased inflammatory response to ozone demonstrate muted signaling of immune cell trafficking pathways

Surface marker (MFI)

R pre ozone

R post ozone

R ozone response*

NR pre ozone

NR post ozone

NR ozone response*

Pre exposure R vs NR

Post exposure R vs NR

Ozone response R vs NR

CD11b Mac

23964 (4448)

44986 (9539)

110 (42)

37861 (11770)

24770 (4280)

8 (30)

ns

P = 0.07

p = 0.05

CD14 Mono

5776 (559)

11800 (1082)

149 (41)

9886 (1016)

19348 (4647)

92 (36)

p = 0.004

ns

ns

HLA-DR Mono

7399 (849)

10611 (832)

85 (35)

9715 (1412)

15361 (2110)

88 (45)

ns

P = 0.02

ns

HLA-DR Mac

46144 (3293)

48527 (5232)

9 (13)

60440 (15219)

76424 (9254)

56 (29)

ns

P = 0.02

ns

CD16 Mac

21259 (6465)

31004 (8624)

100 (38)

8030 (2266)

8988 (2011)

27 (30)

ns

P = 0.01

ns

CD80 Mono

2956 (603)

2236 (576)

16 (49)

825 (370)

1506 (414)

648 (572)

p = 0.01

ns

p = 0.01

CD80 Mac

3202 (611)

5178 (1116)

175 (88)

3440 (1642)

2014 (649)

32 (84)

ns

P = 0.02

ns

CD86 Mac

26012 (2577)

21996 (2422)

172 (193)

42833 (12057)

42135 (9157)

13 (22)

p = 0.05

ns

ns

CD11b Mono

31267 (4186)

32517 (3789)

34 (25)

27031 (3957)

35935 (6247)

47 (25)

ns

ns

ns

CD11b PMN

48975 (3856)

53935 (6220)

18 (16)

51808 (8185)

59310 (9073)

27 (25)

ns

ns

ns

CD14 Mac

7937 (975)

9516 (973)

66 (50)

18093 (10437)

12001 (2838)

9 (14)

ns

ns

ns

HLA-DR DC

27304 (2787)

27230 (2087)

6 (8)

25986 (3583)

29416 (2101)

28 (25)

ns

ns

ns

CD16 Mono

9422 (1763)

7048 (926)

11 (21)

9511 (4755)

6801 (1847)

15 (27)

ns

ns

ns

CD16 PMN

64160 (10852)

62617 (9331)

23 (25)

65491 (29381)

81816 (26611)

65 (30)

ns

ns

ns

CD86 Mono

6768 (893)

6835 (374)

36 (25)

6973 (895)

10588 (10588)

75 (61)

ns

ns

ns

  1. Mean (+/− standard error) values are shown for each cell surface marker, along with the corresponding cell type.
  2. R = Responders; NR = Non-Responders; MFI = mean fluorescence intensity; Mono = monocyte; Mac = macrophage; PMN = Polymorphonuclear neutrophil; ns = not significant.
  3. * Ozone Response values were calculated as the mean of the sum of the individual subject differences in expression (MFI) between post and pre exposure.pre = 48 hours pre exposure; post = 5 hours post exposure.