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Figure 7 | Respiratory Research

Figure 7

From: Heterogeneity of respiratory dendritic cell subsets and lymphocyte populations in inbred mouse strains

Figure 7

Strain heterogeneity of respiratory TNF-α, IFN-γ and IL-10 production. Respiratory leukocytes from inbred mouse strains were purified with CD45-microbeads. TNF-α (A), IFN-γ (B) and IL-10 (C) production were analyzed after T cell (CD3/CD28 mAb), TLR4 (LPS) and TLR9 (CpG ODN 1826) stimulation. BALB/c mice produced significantly higher amounts of TNF-α both after T cell and TLR4 stimulation (A) and higher IFN-γ production after T-cell stimulation when compared to C57BL/6 (BL6) mice (B). IL-10 production was significantly elevated in BALB/c mice after T cell stimulation and LPS stimulation whereas C57BL/6 (BL6) mice produced significantly more IL-10 after TLR9 stimulation when compared to BALB/c mice (C). Results are representative for n≥ 5 independent animals per strain (mean ± SEM; *p<0.05; **p<0.01; ***p<0.001).

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