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Table 2 Mortality (m), mortality rate (MR, per 100 patient-years) in NT-proBNP tertiles, and mortality rate ratio per tertile increase in NT-proNBP

From: NT-proBNP independently predicts long term mortality after acute exacerbation of COPD – a prospective cohort study

 

NT-proBNP (pg/mL)

Mortality Rate Ratio

Tertile 1 (< 264.4)

Tertile 2 (264.4-909)

Tertile 3 (≥909)

Unadjusted

Adjusted*

m (MR)

m (MR)

m (MR)

Gender

    

2.4 (1.8-3.3)

Female

6 (16.5)

12 (35)

12 (67)

2.1 (1.3-3.3)

 

Male

1 (1.9)

8 (39)

18 (51)

2.8 (1.8-4.2)

 

Age, years

    

2.3 (1.6-3.2)

<65

1 (5.4)

1 (70)

1 (15)

1.8 (0.49-6.8)

 

65-74

5 (7.9)

11 (33)

10 (65)

3.3 (1.9-5.6)

 

≥75

1 (11)

8 (39)

19 (60)

1.7 (1.0-2.8)

 

BMI, kg/m2

    

2.3 (1.7-3.2)

<20

2 (9.6)

8 (45)

11 (64)

2.1 (1.2-3.5)

 

≥20

5 (7.2)

9 (30)

18 (50)

2.5 (1.6-3.7)

 

History of DM

    

2.4 (1.7-3.2)

No

6 (7.6)

16 (33)

29 (57)

2.4 (1.7-3.3)

 

Yes

1 (8.8)

4 (21)

1 (44)

2.6 (0.8-8.4)

 

Cephalization

    

2.0 (1.4-2.7)

No

7 (8.0)

19 (37)

13 (31)

1.9 (1.3-2.8)

 

Yes

0

1 (30)

17 (150)

2.2 (1.2-4.2)

 

Atrial fibrillation

    

2.3 (1.7-3.1)

No

7 (8.0)

19 (36)

24 (50)

2.3 (1.6-3.2)

 

Yes

0

1 (41)

6 (109)

2.3 (0.95-5.6)

 

Peripheral edema

    

2.3 (1.7-3.1)

No

5 (6.4)

15 (32)

17 (38)

2.2 (1.5-3.2)

 

Yes

2 (17)

5 (68)

13 (146)

2.4 (1.5-4.1)

 

SaO2 <90%

    

2.3 (1.7-3.1)

No

5 (6.8)

12 (33)

17 (50)

2.5 (1.7-3.8)

 

Yes

2 (12)

8 (42)

13 (68)

1.9 (1.2-3.2)

 

CRP, mg/L

    

2.4 (1.7-3.2)

<50

6 (8.2)

13 (50)

13 (38)

2.0 (1.4-3.1)

 

≥50

1 (6.0)

7 (24)

17 (90)

3.0 (1.8-5.1)

 

hs-cTnT, ng/L

    

1.8 (1.3-2.5)

<14

2 (4.3)

1 (10)

0

0.83 (0.18-3.9)

 

14-40

4 (12)

10 (30)

10 (71)

2.5 (1.5-4.4)

 

≥40

1 (10)

9 (78)

20 (67)

1.5 (0.94-2.3)

 

All, crude MRR

7 (7.8)

20 (36)

30 (56)

2.4 (1.7-3.2)

 
  1. Based on 217 admissions and 57 mortalities among 99 patients. Mortality rate ratio expressed as score test for trend for a one tertile increase in NT-proNBP *Adjusted for the corresponding covariable. BMI, body mass index; DM, diabetes mellitus; CRP, C-reactive protein; hs-cTnT, high-sensitivity cardiac troponin T.