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Table 3 Changes over time in the PAH group

From: Loss of alveolar membrane diffusing capacity and pulmonary capillary blood volume in pulmonary arterial hypertension

Variable

Estimated unit/year change

Wilcoxon SR p-value

FEV1 (ml)

āˆ’144

0.1

FEV1 (%)

āˆ’3

0.12

FVC (ml)

āˆ’190

0.2

FVC (%)

āˆ’5

0.2

FEV1/FVC

0.8

0.4

VA (ml)

20

0.4

FENO (ppb)

0.5

0.4

TLC (%)

0.7

0.5

DLCO (ml/min/mmHg)

āˆ’1.2

0.7

DLNO (ml/min/mmHg)

āˆ’24

0.01

Dm (ml/min/mmHg)

āˆ’12

0.01

Vc (ml)

11

0.07

Dm/Vc (1/min/mmHg)

āˆ’0.4

0.04

Hgb (g/dl)

0.05

0.6

  1. FENO: fractional exhaled nitric oxide.
  2. FVC: forced vital capacity.
  3. FEV1: forced expiratory volume in one second.
  4. TLC: total lung capacity.
  5. Va: alveolar volume.
  6. DL: lung diffusion for carbon monoxide (DLCO) and for nitric oxide (DLNO).
  7. Dm: alveolar-capillary membrane diffusing capacity.
  8. Vc: lung capillary blood volume.
  9. Hgb: hemoglobin.