Figure 3

Recruitment of CD3+ T Cells and Macrophages. Bright field images of each section are shown in the left panel and corresponding fluorescent images are on the right. Images of control lung sections from sham-treated C57/Bl6 (A) and PPARγ KO (B) mice stained with anti-CD3 demonstrate minimal CD3+ staining. In contrast, lung tissue sections from MWCNT-instilled PPARγ KO mice exhibit marked CD3+ staining in association with granulomatous foci (C). Minimal MOMA staining is found in control lung tissue sections from sham treated C57Bl/6 (D) and PPARγ KO (E) mice. In MWCNT-instilled PPARγ KO mice, lung sections show prominent MOMA staining localizing with granulomatous foci (F).