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Figure 2 | Respiratory Research

Figure 2

From: Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses

Figure 2

Treatment with sivelestat reduces airway inflammation 6 hr after secondary challenge. (A) H&E–stained lung tissue (final magnification:x400). (a) PBS/OVA/vehicle/OVA, (b) OVA/OVA/vehicle/OVA, (c) OVA/OVA/Sivelestat/OVA. (B) Inflammatory cell numbers in the peribronchial and perivascular tissue were measured (final magnification:x1000). (C) Anti-Gr-1 monoclonal antibody stained lung tissue (final magnification:x400). (a) PBS/OVA/vehicle/OVA, (b) OVA/OVA/vehicle/OVA, (c) OVA/OVA/Sivelestat/OVA. (D) Treatment with sivelestat suppresses goblet cell metaplasia. PAS staining was performed to identify mucus-containing cells in the airway epithelium (final magnification:x1000). (a) PBS/OVA/vehicle/OVA, (b) OVA/OVA/vehicle/OVA, (c) OVA/OVA/Sivelestat/OVA. (E) The number of mucus-positive cells. Data represent the mean ± SD. (n = 8 in each group). *Significant differences (P<0.05) between PBS/OVA/vehicle/OVA and OVA/OVA/vehicle/OVA. #Significant differences (P<0.05) between OVA/OVA/vehicle/OVA and OVA/OVA/Sivelestat/OVA.

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