Mesenchymal stem cells promote alveolar epithelial cell wound repair in vitro through distinct migratory and paracrine mechanisms

Akram, Khondoker M; Samad, Sohel; Spiteri, Monica A; Forsyth, Nicholas R

doi:10.1186/1465-9921-14-9

Table 1 Protein components of SF-MSC CM detected by LC-MS/MS mass spectrometry

From: Mesenchymal stem cells promote alveolar epithelial cell wound repair in vitro through distinct migratory and paracrine mechanisms

Protein name	Accession number	Average Peptide count
Fibronectin 1, isoform CRA_j	gi\|119590945	39.0
Collagen alpha-2(I) chain	gi\|124056488	30.0
Collagen alpha 1 chain precursor variant	gi\|62088774	23.5
Pro alpha 1(I) collagen	gi\|186893270	23.5
Alpha 1 (I) chain propeptide	gi\|180392	21.3
Collagen, type VI, alpha 1 precursor	gi\|87196339	11.0
Precursor polypeptide (AA −31 to 1139)	gi\|37465	7.5
Actin, gamma 1 propeptide	gi\|4501887	7.0
Gelatinase A	gi\|5822007	6.7
Keratin 1	gi\|7331218	6.5
Tumor necrosis factor	gi\|339992	6.3
Osteoblast specific factor 2 (Periostin)	gi\|393319	6.0
Chain A, Crystal Structure Of The Thrombospondin-1	gi\|88191917	5.5
Biglycan	gi\|179433	4.7
Lumican	gi\|642534	4.7
Collagen alpha 1(V) chain precursor	gi\|219510	4.5
Insulin-like growth factor binding protein 7, isoform CRA_a	gi\|119625925	4.5
CALU	gi\|49456627	4.0
Thrombospondin 2 precursor	gi\|40317628	4.0
Fructose-bisphosphate aldolase A	gi\|4557305	3.5
Heparan sulfate proteoglycan	gi\|184427	3.5
Pigment epithelium-derived factor	gi\|1144299	3.5
Profilin Binds Proline	gi\|5822002	3.0
Protein disulfide isomerase	gi\|860986	3.0
Versican isoform 3 precursor	gi\|255918077	3.0
Decorin	gi\|181519	2.7
The Antigenic Identity Of Peptide(Slash)mhc Complexes	gi\|442989	2.5
COL1A1 and PDGFB fusion transcript	gi\|3288487	2.5
Peptidylprolyl isomerase A	gi\|10863927	2.5
Fibrillin	gi\|306746	2.0
Similar to cardiac leiomodin	gi\|51095092	2.0
Solution Structure Of Calcium-Calmodulin N-Terminal Domain	gi\|16974825	1.7
Myosin, light chain 6, alkali, smooth muscle and non-muscle isoform 1	gi\|17986258	1.5
Protein disulfide-isomerase A3	gi\|729433	1.5
Insulin-like growth factor binding protein 6	gi\|183894	1.0

SF-MSC CM preparation was as described in Materials and Methods. Proteins selected for investigations in wound repair and migration are indicated in bold. Accession numbers are derived from MS/MS data searches against non redundant Human NCBI Protein Database. Average peptide count from 3 biologically independent replicates of hMSC secretome profiles.

Back to article page

ISSN: 1465-993X

Contact us

General enquiries: journalsubmissions@springernature.com

Respiratory Research

Contact us