Figure 3

Morphometry and lung mechanics. (A) Lungs of mice exposed to RA, CS, HK-NTHi or CS/HK-NTHi were inflated to an identical pressure, processed for paraffin embedding and sections at different depth were stained with H & E. The diameters of the air spaces were measured in at least 10 random fields per slide.. Mice were anesthetized and dynamic compliance (B) and elastance (C) and pressure-volume relationships (D) were measured using Flexivent system. Data in A to C represent median with range calculated from 5 to 6 mice per group (* different from RA-exposed mice, p ≤ 0.05, ANOVA on ranks; # different from RA/HK-NTHi-exposed mice, p ≤ 0.05, ANOVA on ranks; † different from CS-exposed mice, p ≤ 0.05, ANOVA on ranks).