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Figure 9 | Respiratory Research

Figure 9

From: Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis

Figure 9

Outline of experimental design in a therapeutic setting. Osmotic pumps containing 200 μL saline with or without bleomycin (BLM; 100 mg/kg) were implanted subcutaneously according to the manufacturer’s instructions. BLM was infused constantly from day 0 to day 6. Pirfenidone (300 mg/kg/day) was orally administered every 12 h from day 10 to day 20. On day 21 of BLM injection, the mice were killed and their lungs were removed for analysis. Each experiment was performed with at least 6 mice per group.

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