All patients (n = 240) | No Aspergillusspp. isolation (n = 120)# | Aspergillusspp. isolation (n = 24)# | p-value† | |
---|---|---|---|---|
Age, years | 74.4 ± 8.8 | 74.2 ± 10.1 | 73.1 ± 8.2 | 0.569 |
Gender, males | 217 (90.4) | 103 (85.8) | 23 (95.8) | 0.246 |
Past-smoker | 175 (72.6) | 87(72.5) | 18 (75.0) | 0.608 |
Current smoker | 65 (27.4) | 33 (27.5) | 6 (25.0) | 0.779 |
FEV1% predicted | 2.6 (1-3) | 47.3 ± 12.9 | 45.4 ± 14.7 | 0.196 |
FVC% predicted | 44.0 ± 14.6 | 71.9 ± 14.4 | 68.8 ± 16.4 | 0.094 |
Charlson index | 69.6 ± 19.6 | 2.1 (1.3-3.4) | 2.7 (1.6-3.9) | 0.060 |
GOLD stage II | 12 (5,8) | 8 (6.6) | - | - |
GOLD stage III | 92 (38,3) | 46 (38.3) | 8 (33.3) | 0.436 |
GOLD stage IV | 136 (56,1) | 66 (55.5) | 16 (66.6) | 0.062 |
COPD exacerbation in the previous year | ||||
≤ 2 exacerbations | 82 (53.2) | 65 (63.7) | 7 (38.8) | 0.150 |
>2 exacerbations | 72 (46.7) | 37 (36.3) | 11 (61.1) | 0.050 |
Admission for COPD in the previous year | 2.6 ± 1.9 | 2.1 ± 0.8 | 2.4 ± 1.2 | 0.079 |
Long Term Oxygen Therapy | 72 (30.0) | 36 (29.1) | 9 (37.5) | 0.067 |
Cardiovascular disease1 | 131 (54.6) | 61 (50.8) | 12 (50.0) | 0.475 |
Arterial hypertension2 | 112 (46.7) | 52 (43.3) | 19 (79.2) | 0.002 |
Diabetes mellitus | 65 (27.1) | 31 (25.8) | 9 (37.5) | 0.206 |
Chronic renal disease | 34 (14.2) | 15 (12.5) | 6 (25.0) | 0.052 |
Inhaled corticosteroids | 170 (70.8) | 85 (70.8) | 18 (75.0) | 0.763 |
<500 mcg daily | 106 (62.3) | 54 (43.5) | 12 (66.6) | 0.096 |
>500 mcg daily | 64 (37.6) | 31 (36.5) | 6 (33.3) | 0.267 |
Oral corticosteroids | 80 (33.3) | 39 (32.5) | 9 (37.5) | 0.284 |