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Table 1 The effect of potassium channel inhibitors on chloroquine-mediated relaxation of mouse small airways

From: Rosiglitazone is a superior bronchodilator compared to chloroquine and β-adrenoceptor agonists in mouse lung slices

 

n

% Relaxation

  

Inhibitor alone

Inhibitor + CQ

Vehicle

8

1.2 ± 2.1

88.1 ± 4.9

TEA (1 mM)

4

36.3 ± 7.8***

39.8 ± 3.2^^^

Glibenclamide (1 μM)

4

0.6 ± 2.4

89.3 ± 2.9

Apamin (500 nM)

4

0.1 ± 2.5

92.8 ± 3.7

Charybdotoxin (10 nM)

4

5.2 ± 2.1

83.4 ± 11.1

  1. Airways were pre-contracted with 100nM MCh prior to perfusion for 5 min in the presence of inhibitor alone, followed by inhibitor and chloroquine (10 μM). Responses (mean ± S.E.M) represent the% relaxation of the pre-contraction to MCh, averaged over the last minute of perfusion. ***p < 0.0001 cf vehicle. ^^^p < 0.0001 cf CQ alone.