A randomized clinical trial to assess the influence of a three months training program (Gym-based individualized vs. Calisthenics-based non-invidualized) in COPD-patients

Table 6 Serum markers of inflammation and myokines

	IT		p-value	NT		p-value	p-value
	M₁	M₂	p-value	M₁	M₂	p-value	p-value
CRP [mg/l]	5.6 + 2.1	6.2 + 2.4	1.000	5 + 0	5.2 + 0.6	0.180	0.419
WBC [G/l]	7.5 + 2.1	7.4 + 2.3	0.619	7.2 + 2.1	6.9 + 2.1	0.198	0.666
IL-6 [ng/l]	4.9 + 7.9	3.6 + 2.1	0.324	3.8 + 3.1	5.8 + 6.4	0.170	0.653
IL-8 [ng/l]	8.4 + 3.0	8.8 + 2.9	0.569	8.8 + 2.8	9.4 + 3.6	0.362	0.691
TNF-α [ng/l]	9.9 + 3.5	9.1 + 2.9	0.528	10.7 + 2.9	10.7 + 3.1	0.889	0.587
PGC1- α [relative copies]	0.77 ± 0.77	1.2 ± 1.15	0.017	1.03 ± 0.77	1.16 ± 0.81	0.388	0.832
Irisin [ng/μl]	128.65 ± 14.87	131.5 ± 33.26	0.528	123.67 ± 17.85	128.86 ± 16.68	0.136	0.138

Wilcoxon rank-sum test for paired samples was used to test for significant differences between measurement 1 (M1: before the program) and measurement 2 (M2: after the program). To compare the deltas (M2-M2) between both groups, the Mann–Whitney-U-Test for unpaired samples was performed. Abbreviations are explained in the text.

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