Table 1 Arterial blood gases
Variable | ARDSp | ARDSexp | ||||||
|---|---|---|---|---|---|---|---|---|
CTRL-it | SALB-it | CTRL-iv | SALB-iv | CTRL-it | SALB-it | CTRL-iv | SALB-iv | |
PaO 2 [mmHg (kPa)] | ||||||||
BL1 | 236 ± 61 | 238 ± 66 | 227 ± 50 | 200 ± 46 | 249 ± 36 | 249 ± 50 | 241 ± 42 | 244 ± 51 |
(31.5 ± 8.0) | (31.8 ± 8.8) | (30.3 ± 6.6) | (26.7 ± 6.1) | (33.2 ± 4.9) | (33.2 ± 6.6) | (32.2 ± 5.6) | (32.5 ± 6.8) | |
BL2 | 230 ± 88 | 249 ± 65 | 238 ± 74 | 246 ± 69 | 279 ± 79 | 292 ± 75 | 212 ± 62 | 257 ± 97 |
(30.7 ± 11.8) | (33.2 ± 8.7) | (31.7 ± 9.9) | (32.8 ± 9.3) | (37.2 ± 10.5) | (39.0 ± 10.0) | (28.2 ± 8.3) | (34.1 ± 12.9) | |
T30 | 191 ± 50 | 210 ± 34 | 175 ± 43 | 183 ± 57 | 225 ± 57 | 226 ± 39 | 212 ± 55 | 244 ± 55 |
(25.5 ± 6.6) | (28.0 ± 4.5) | (23.4 ± 5.7) | (24.4 ± 7.6) | (30.0 ± 7.7) | (30.1 ± 5.2) | (28.3 ± 7.3) | (32.6 ± 7.3) | |
T60 | 196 ± 84 | 205 ± 43 | 215 ± 72 | 214 ± 84 | 252 ± 46 | 222 ± 42 | 208 ± 27 | 251 ± 68 |
(26.1 ± 11.1) | (27.2 ± 5.7) | (28.7 ± 9.6) | (28.5 ± 11.2) | (33.6 ± 6.1) | (29.5 ± 5.6) | (27.6 ± 3.6) | (33.5 ± 9.1) | |
Time effect | p < 0.01 | ns | ||||||
Interaction | Ns | ns | ||||||
Group effect | Ns | ns | ||||||
PaCO 2 [mmHg (kPa)] | ||||||||
BL1 | 34 ± 6 | 34 ± 5 | 34 ± 7 | 36 ± 6 | 33 ± 6 | 31 ± 7 | 31 ± 7 | 27 ± 4 |
(4.6 ± 0.7) | (4.6 ± 0.7) | (4.5 ± 0.9) | (4.8 ± 0.8) | (4.4 ± 0.8) | (4.2 ± 0.9) | (4.1 ± 0.9) | (3.6 ± 0.6) | |
BL2 | 50 ± 7 | 43 ± 6 | 45 ± 6 | 50 ± 11 | 40 ± 7 | 42 ± 5 | 43 ± 9 | 39 ± 11 |
(6.7 ± 0.9) | (5.7 ± 0.9) | (6.0 ± 0.8) | (6.7 ± 1.5) | (5.3 ± 1.0) | (5.6 ± 0.7) | (5.8 ± 1.2) | (5.2 ± 1.5) | |
T30 | 59 ± 13 | 47 ± 18 | 55 ± 12 | 58 ± 12 | 45 ± 9 | 56 ± 12 | 51 ± 11 | 44 ± 12 |
(7.8 ± 1.8) | (6.3 ± 2.4) | (7.4 ± 1.6) | (7.8 ± 1.6) | (6.0 ± 1.2) | (7.5 ± 1.6) | (6.9 ± 1.5) | (5.8 ± 1.6) | |
T60 | 55 ± 16 | 55 ± 16 | 55 ± 9 | 48 ± 13 | 46 ± 11 | 55 ± 13 | 53 ± 8 | 52 ± 7 |
(7.4 ± 2.0) | (7.3 ± 2.2) | (7.3 ± 1.15) | (6.4 ± 1.7) | (6.2 ± 1.5) | (7.3 ± 1.7) | (7.0 ± 1.1) | (7.0 ± 0.9) | |
Time effect | p < 0.01 | p < 0.001 | ||||||
Interaction | Ns | ns | ||||||
Group effect | Ns | ns | ||||||
pHa | ||||||||
BL1 | 7.43 ± 0.08 | 7.44 ± 0.05 | 7.46 ± 0.06 | 7.46 ± 0.06 | 7.43 ± 0.05 | 7.45 ± 0.05 | 7.45 ± 0.07 | 7.46 ± 0.06 |
BL2 | 7.30 ± 0.04 | 7.36 ± 0.06 | 7.33 ± 0.04 | 7.30 ± 0.06 | 7.32 ± 0.04 | 7.31 ± 0.04 | 7.32 ± 0.04 | 7.30 ± 0.06 |
T30 | 7.24 ± 0.07 | 7.29 ± 0.07 | 7.28 ± 0.08 | 7.25 ± 0.08 | 7.24 ± 0.03 | 7.19 ± 0.09 | 7.23 ± 0.06 | 7.25 ± 0.08 |
T60 | 7.24 ± 0.10 | 7.26 ± 0.08 | 7.28 ± 0.05 | 7.27 ± 011 | 7.25 ± 0.04 | 7.16 ± 0.10 | 7.20 ± 0.07 | 7.25 ± 0.07 |
Time effect | p < 0.001 | p < 0.001 | ||||||
Interaction | Ns | ns | ||||||
Group effect | Ns | p < 0.01 | ||||||
BE [mmol/L] | ||||||||
BL1 | −1 ± 4 | −1 ± 2 | 0 ± 3 | 2 ± 1 | −3 ± 2 | −2 ± 3 | −4 ± 2 | 5 ± 1 |
BL2 | −1 ± 2 | −3 ± 2 | −2 ± 1 | −3 ± 1 | −6 ± 4 | −5 ± 4 | −4 ± 4 | −5 ± 2 |
T30 | −3 ± 4 | −5 ± 4 | −1 ± 2 | −2 ± 2 | −8 ± 4 | −6 ± 5 | −6 ± 4 | −6 ± 3 |
T60 | −4 ± 6 | −3 ± 2 | −1 ± 3 | −5 ± 4 | −7 ± 4 | −9 ± 6 | −7 ± 4 | −4 ± 3 |
Time effect | p < 0.05 | ns | ||||||
Interaction | Ns | ns | ||||||
Group effect | Ns | ns | ||||||
HCO 3 [mmol/L] | ||||||||
BL1 | 23.1 ± 2.7 | 23.6 ± 2.3 | 24.5 ± 2.3 | 26.0 ± 1.6 | 22.0 ± 2.6 | 22.0 ± 2.9 | 21.0 ± 2.4 | 19.5 ± 1.3 |
BL2 | 25.3 ± 1.7 | 23.1 ± 1.5 | 24.2 ± 0.9 | 24.3 ± 2.3 | 20.7 ± 3.6 | 21.8 ± 3.3 | 22.6 ± 4.0 | 21.6 ± 1.7 |
T30 | 24.4 ± 3.3 | 22.2 ± 5.2 | 26.2 ± 2.0 | 25.5 ± 2.1 | 20.0 ± 3.7 | 22.0 ± 4.5 | 22.2 ± 3.7 | 21.9 ± 1.8 |
T60 | 23.9 ± 5.3 | 24.7 ± 2.9 | 26.0 ± 2.8 | 21.9 ± 4.0 | 20.8 ± 4.1 | 20.2 ± 5.0 | 24.8 ± 10.8 | 23.2 ± 2.3 |
Time effect | Ns | ns | ||||||
Interaction | Ns | ns | ||||||
Group effect | Ns | ns | ||||||