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Table 5 Common lncRNA expression changes in healthy ASM cells after treatment with FCS or Dex + FCS

From: Role of non-coding RNAs in maintaining primary airway smooth muscle cells

   

FCS

Dex + FCS

Class of lncRNA

Ensemble gene ID

Transcript

Microarray (FC)

Microarray (FC)

Known sense overlapping

ENST00000314957

CTD-2201E18.3

−1.73 (<.01)

1.78 (<.05)

lincRNA

ENST00000414120

LINC00887

−1.81 (<.05)

−1.93 (<.01)

Known antisense

ENST00000415647

RP11-46A10.4

−1.62 (<.05)

−1.65 (<.05)

lincRNA

ENST00000417485

AC012668.2

−2.28 (<.01)

−1.81 (<.01)

lincRNA

ENST00000418539

BCYRN1

−1.53 (<.05)

2.37 (<.05)

Known antisense

ENST00000420095

LMCD1-AS1

−1.57 (<.05)

5.65 (<.05)

lincRNA

ENST00000426635

LINC00472

1.86 (<.05)

2.64 (<.05)

lincRNA

ENST00000431759

SLC2A1-AS1

−1.95 (<.05)

−2.09 (<.05)

lincRNA

ENST00000433843

SNHG5

−1.74 (<.05)

−1.51 (<.01)

lincRNA

ENST00000442316

AC074363.1

−1.60 (<.05)

−1.62 (<.05)

lincRNA

ENST00000444958

DANCR

2.59 (<.05)

2.38 (<.05)

Known antisense

ENST00000446423

SDCBP2

−1.82 (<.05)

−1.82 (<.05)

lincRNA

ENST00000448738

RP1-295F6.2

1.62 (<.05)

1.53 (<.05)

lincRNA

ENST00000451910

RP11-344J7.2

2.06 (<.01)

1.66 (<.05)

Known retained intron

ENST00000453698

SNHG11

−2.85 (<.01)

−2.24 (<.01)

lincRNA

ENST00000473636

LINC00882

2.14 (<.05)

2.08 (<.05)

lincRNA

ENST00000495228

LINC00883

1.63 (<.05)

1.78 (<.05)

lincRNA

ENST00000505448

RP11-774O3.3

−1.57 (<.001)

−1.66 (<.05)

Known antisense

ENST00000507963

NR2F1-AS1

−1.66 (<.05)

−1.61 (<.05)

Known antisense

ENST00000509179

MEF2C-AS1

−2.59 (<.05)

−2.16 (<.01)

lincRNA

ENST00000515296

CTB-35F21.1

−1.83 (<.05)

−1.94 (<.05)

lincRNA

ENST00000515306

CTB-35F21.2

−2.23 (<.05)

−2.15 (<.05)

lincRNA

ENST00000515871

CTC-325J23.3

1.60 (<.05)

1.72 (<.01)

lincRNA

ENST00000518765

RP11-527N22.1

−1.69 (<.05)

−1.53 (<.05)

lincRNA

ENST00000518771

RP11-37B2.1

−1.85 (<.001)

−1.71 (<.001)

lincRNA

ENST00000521128

CTB-43E15.3

−2.07 (<.05)

−2.06 (<.05)

lincRNA

ENST00000523242

CTB-43E15.1

−1.79 (<.05)

−2.02 (<.05)

lincRNA

ENST00000523328

PVT1

1.39 (<.01)

1.66 (<.001)

lincRNA

ENST00000538996

AP003486.1

−2.69 (<.01)

−1.81 (<.05)

  1. This table lists those lncRNAs that have been manually annotated in the Ensembl database and the expression of which is significantly changed in healthy ASM cells after stimulation with FCS (2.5%) or treatment with dexamethasone (10−7 M) before stimulation with FCS (2.5%). Microarray data are denoted as the fold change against baseline control and is the mean of 9 individual patients. These values are for those genes that demonstrated an FDR of less than 0.05; associated P values are shown.