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Table 3 Multivariate models of the effect of GERD on different COPD outcomes among participants in COPDGene (n = 4,483)*

From: Impact of self-reported Gastroesophageal reflux disease in subjects from COPDGene cohort

 

Model 1 GERD diagnosis Regression coefficient or OR (95% CI)

Model 2 Additionally adjusted for propensity to be diagnosed with GERD Regression coefficient or OR (95% CI)

Model 3 Additionally adjusted for PPIs use and GERD-PPIs Interaction Regression coefficient or OR (95% CI)

Outcome: SGRQ score symptoms

GERD

7.40 (5.93, 8.87)

2.48 (1.01, 3.95)

3.40 (1.56, 5.22)

PPI use

  

4.19 (1.09, 7.28)

GERD*PPIs interaction (p-value)

  

0.006

Outcome: SGRQ score activity

GERD

6.35 (4.83, 7.81)

3.00 (1.46, 4.55)

3.82 (1.90, 5.75)

PPI use

  

3.63 (0.37, 6.88)

GERD*PPIs interaction (p-value)

  

0.021

Outcome: SGRQ score impact

GERD

5.48 (4.27, 6.69)

2.34 (1.10, 3.58)

3.09 (1.55, 4.64)

PPI use

  

3.75 (1.14, 6.36)

GERD*PPIs Interaction (p-value)

  

0.005

Outcome: SGRQ total score

GERD

6.05 (4.85, 7.26)

2.58 (1.36, 3.80)

3.38 (1.86, 4.90)

PPI use

  

3.77 (1.19, 6.34)

GERD*PPIs interaction (p-value)

  

0.003

Outcome: Count of exacerbations in the year prior to enrollment**

GERD

1.32 (1.21, 1.44)

1.16 (1.06, 1.27)

1.17 (1.05, 1.31)

PPI use

  

1.20 (1.00, 1.44)

GERD*PPIs interaction

  

NS

Outcome: Frequent exacerbator at enrollment

GERD

1.88 (1.57, 2.24)

1.41 (1.17, 1.71)

1.40 (1.10, 1.77)

PPI use

  

1.60 (1.09, 2.35)

GERD*PPIs interaction

  

NS

Outcome: Frequent exacerbator at follow-up

GERD

1.81 (1.52, 2.16)

1.50 (1.24, 1.82)

1.40 (1.10, 1.79)

PPI Use

  

1.56 (1.06, 2.30)

GERD*PPIs interaction

  

NS

  1. *All models additionally adjusted for age, gender, BMI, current smoking, FEV1% predicted and clinical center.
  2. **Zero-inflated Poisson model.